Peptide Libraray

Sungsanpin

General Information

DCTPep ID DCTPep00464

Peptide Name Sungsanpin

Sequence GFGSKPIDSFGLSWL

Sequence Length 15

UniProt ID Not available

PubChem CID Not available

Origin Streptomyces

Type Native peptide

Classification

Cancer therapy related peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	10% Killing=50µM; 25% Inhibition=5µM(In a cell invasion assay); 30% Killing=100µM; 47% Inhibition=50µM(In a cell invasion assay)	CCK-8 assay; cell invasion assay kit(cell invasion)	24h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00464

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond LAC: Gly1<--->Asp8

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C77H111N17O21

Absent amino acids ACEHMNQRTVY

Theoretical pI 5.84

Acidic residues 1

Basic residues 1

Polar residues 6

Molecular weight (Average) 1610.83

Molecular weight (Monoisotopic) 1609.81

Common amino acids GS

Net charge 0

Instability index (II) 25.37

Aliphatic index 78.00

Grand average of hydropathicity (GRAVY) 0.280

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 3.414

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 23662937

Title Sungsanpin, a lasso peptide from a deep-sea streptomycete

Doi 10.1021/np300902g

Year 2013

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available