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TsAP-2 (T. serrulatus antimicrobial peptide 2)
General Information
DCTPep ID DCTPep00466
Peptide Name TsAP-2 (T. serrulatus antimicrobial peptide 2)
Sequence FLGMIPGLIGGLISAFK
Sequence Length 17
PubChem CID Not available
Origin Tityus serrulatus (Brazilian yellow scorpion)
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| NCI-H838 | Lung adenocarcinoma | IC50=11.0μM | MTT assay | 24h | 1 |
| PC-3 | Prostate carcinoma | IC50=13.3μM | MTT assay | 24h | 1 |
| U-251MG | Astrocytoma | IC50=15.4μM | MTT assay | 24h | 1 |
| NCI-H157 | Lung squamous cell carcinoma | IC50=4.1μM | MTT assay | 24h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | IC50=6.4μM | MTT assay | 24h | 1 |
Hemolytic Activity Horse erythrocytes(possess little haemolytic activity (6.48%) at the highest concentration tested (160 μM) )
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00466
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C84H136N18O19S1
Absent amino acids CDEHNQRTVWY
Theoretical pI 8.75
Acidic residues 0
Basic residues 1
Polar residues 5
Molecular weight (Average) 1734.17
Molecular weight (Monoisotopic) 1732.99
Common amino acids G
Net charge 1
Instability index (II) 6.14
Aliphatic index 143.53
Grand average of hydropathicity (GRAVY) 1.547
Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23770440
Title Two peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: evaluation of their antimicrobial and anticancer activities
Doi 10.1016/j.biochi.2013.06.003
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.