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BP16
General Information
DCTPep ID DCTPep00469
Peptide Name BP16
Sequence KKLFKKILKKL
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cell-penetrating peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | IC50>200 µM | MTT assay | 48 h | 1 |
| CAPAN-1 | Pancreatic ductal adenocarcinoma | IC50>200 µM | MTT assay | 48 h | 1 |
Hemolytic Activity Human erythrocytes: 0% Hemolysis=150 µM
Normal (non-cancerous) Cytotoxicity NIH 3T3: IC50>200 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C69H127N17O12
Absent amino acids ACDEGHMNPQRSTVWY
Theoretical pI 10.70
Acidic residues 0
Basic residues 6
Polar residues 0
Molecular weight (Average) 1386.87
Molecular weight (Monoisotopic) 1385.98
Common amino acids K
Net charge 6
Instability index (II) -17.94
Aliphatic index 141.82
Grand average of hydropathicity (GRAVY) -0.427
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24480922
Title Identification of BP16 as a non-toxic cell-penetrating peptide with highly efficient drug delivery properties
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_6046
This work is licensed under a Creative Commons Attribution 4.0 International License.