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BP81
General Information
DCTPep ID DCTPep00470
Peptide Name BP81
Sequence LKLFKKILKFL
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Cell-penetrating peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| CAPAN-1 | Pancreatic ductal adenocarcinoma | IC50=24.2 ± 7.2 µM | MTT assay | 48 h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | IC50=40.0 ± 3.4 µM | MTT assay | 48 h | 1 |
Hemolytic Activity Human erythrocytes: 15.5 ± 0.7% Hemolysis=150 µM
Normal (non-cancerous) Cytotoxicity NIH 3T3: IC50=15.5 ± 0.7 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C72H123N15O12
Absent amino acids ACDEGHMNPQRSTVWY
Theoretical pI 10.48
Acidic residues 0
Basic residues 4
Polar residues 0
Molecular weight (Average) 1390.86
Molecular weight (Monoisotopic) 1389.95
Common amino acids KL
Net charge 4
Instability index (II) -17.94
Aliphatic index 177.27
Grand average of hydropathicity (GRAVY) 0.882
Half Life
5.5 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24480922
Title Identification of BP16 as a non-toxic cell-penetrating peptide with highly efficient drug delivery properties
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_4984
This work is licensed under a Creative Commons Attribution 4.0 International License.