This work is licensed under a Creative Commons Attribution 4.0 International License.
Bac2a [L2R][A3W][A11R]
General Information
DCTPep ID DCTPep00474
Peptide Name Bac2a [L2R][A3W][A11R]
Sequence RRWRIVVIRVRR
Sequence Length 12
UniProt ID Not available
PubChem CID 71588776
Origin Synthetic
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | IC50>50 µM | Resazurin assay | 2h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis>50 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C74H133N31O13
Absent amino acids ACDEFGHKLMNPQSTY
Theoretical pI 12.70
Acidic residues 0
Basic residues 6
Polar residues 0
Molecular weight (Average) 1665.07
Molecular weight (Monoisotopic) 1664.07
Common amino acids R
Net charge 6
Instability index (II) 145.29
Aliphatic index 137.50
Grand average of hydropathicity (GRAVY) -0.525
Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 3.303
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24038773
Title The antimicrobial activity of Sub3 is dependent on membrane binding and cell-penetrating ability
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.