This work is licensed under a Creative Commons Attribution 4.0 International License.
Drosocin-1
General Information
DCTPep ID DCTPep00476
Peptide Name Drosocin-1
Sequence GKPRPYSPRPTSHPRPIRV
Sequence Length 19
UniProt ID Not available
PubChem CID 16131048
Origin Drosophila melanogaster; Drosophila simulans
Type Native peptide
Classification
Cancer therapy related peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HepG2 | Hepatoblastoma | Not active up to 600 µg/ml | Not available | Not available | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Not active up to 601 µg/ml | Not available | Not available | 1 |
Hemolytic Activity Mouse erythrocytes: <10% Hemolysis=100 µM; Pig erythrocytes: <10% Hemolysis=100 µM; Human erythrocytes: Not active up to 600 µg/ml
Normal (non-cancerous) Cytotoxicity CEM-SS cells: 50% Cell death>45.5 µM; HEK293: Not active up to 600 µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00476
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C98H160N34O24
Absent amino acids ACDEFLMNQW
Theoretical pI 12.01
Acidic residues 0
Basic residues 6
Polar residues 5
Molecular weight (Average) 2198.56
Molecular weight (Monoisotopic) 2197.23
Common amino acids P
Net charge 6
Instability index (II) 41.15
Aliphatic index 35.79
Grand average of hydropathicity (GRAVY) -1.579
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.678
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24164265
Title Hydroxyproline substitutions stabilize non-glycosylated drosocin against serum proteases without challenging its antibacterial activity
Doi 10.2174/09298665113206660105
Year 2014
Literature 2
Pubmed ID 31001677
Title The Drosophila melanogaster antimicrobial peptides Mtk-1 and Mtk-2 are active against the malarial parasite Plasmodium falciparum
Doi 10.1007/s00436-019-06305-x
Year 2019
Literature 3
Pubmed ID 20086159
Title Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database
Year 2010
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.