This work is licensed under a Creative Commons Attribution 4.0 International License.
Cecropin A (2-8) + Melittin (6-9)
General Information
DCTPep ID DCTPep00481
Peptide Name Cecropin A (2-8) + Melittin (6-9)
Sequence WKLFKKILKVL
Sequence Length 11
UniProt ID Not available
PubChem CID 76319137
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| Raji | EBV-related Burkitt lymphoma; Burkitt lymphoma | IC50=15 µg/ml | MTT assay | Not available | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | IC50=18 µg/ml | MTT assay | Not available | 1 |
| LNCaP | Prostate carcinoma | IC50=4 µg/ml | MTT assay | Not available | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis=104 µM; 56% Hemolysis=150 µM
Normal (non-cancerous) Cytotoxicity CHO: 50% Cell death=13 µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C73H122N16O12
Absent amino acids ACDEGHMNPQRSTY
Theoretical pI 10.48
Acidic residues 0
Basic residues 4
Polar residues 0
Molecular weight (Average) 1415.87
Molecular weight (Monoisotopic) 1414.94
Common amino acids K
Net charge 4
Instability index (II) -17.94
Aliphatic index 168.18
Grand average of hydropathicity (GRAVY) 0.582
Half Life
2.8 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 3.885
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24323118
Title Investigation of the antibacterial activity of a short cationic peptide against multidrug-resistant Klebsiella pneumoniae and Salmonella typhimurium strains and its cytotoxicity on eukaryotic cells
Year 2014
Literature 2
Pubmed ID 16672470
Title Inhibition of plant-pathogenic bacteria by short synthetic cecropin A-melittin hybrid peptides
Doi 10.1128/AEM.72.5.3302-3308.2006
Year 2006
Literature 3
Pubmed ID 19617390
Title Sporicidal activity of synthetic antifungal undecapeptides and control of Penicillium rot of apples
Year 2009
Literature 4
Title
Year
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.