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BP327
General Information
DCTPep ID DCTPep00482
Peptide Name BP327
Sequence CREKAKKLFKKILKKL
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Coupling peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | IC50=74.7±8.8µM | MTT assay | 48h | 1 |
| CAPAN-1 | Pancreatic ductal adenocarcinoma | IC50=76.2±0.8µM | MTT assay | 48h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity NIH 3T3: IC50=74.5±4.1µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00482
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C92H168N26O19S1
Absent amino acids DGHMNPQSTVWY
Theoretical pI 10.40
Acidic residues 1
Basic residues 8
Polar residues 1
Molecular weight (Average) 1974.57
Molecular weight (Monoisotopic) 1973.27
Common amino acids K
Net charge 7
Instability index (II) -9.21
Aliphatic index 103.75
Grand average of hydropathicity (GRAVY) -0.769
Half Life
1.2 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24480922
Title Identification of BP16 as a non-toxic cell-penetrating peptide with highly efficient drug delivery properties
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_10332
This work is licensed under a Creative Commons Attribution 4.0 International License.