This work is licensed under a Creative Commons Attribution 4.0 International License.
BP308
General Information
DCTPep ID DCTPep00483
Peptide Name BP308
Sequence RRLFRRILRRL
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Cell-penetrating peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | IC50=148.2±8.8µM | MTT assay | 48h | 1 |
| CAPAN-1 | Pancreatic ductal adenocarcinoma | IC50=97.0±15.4µM | MTT assay | 48h | 1 |
Hemolytic Activity Human erythrocytes: 1±0.1% Hemolysis=150µM
Normal (non-cancerous) Cytotoxicity NIH 3T3: IC50=68.0±7.6µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C69H127N29O12
Absent amino acids ACDEGHKMNPQSTVWY
Theoretical pI 12.70
Acidic residues 0
Basic residues 6
Polar residues 0
Molecular weight (Average) 1554.95
Molecular weight (Monoisotopic) 1554.02
Common amino acids R
Net charge 6
Instability index (II) 200.33
Aliphatic index 141.82
Grand average of hydropathicity (GRAVY) -0.755
Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24480922
Title Identification of BP16 as a non-toxic cell-penetrating peptide with highly efficient drug delivery properties
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_10330
This work is licensed under a Creative Commons Attribution 4.0 International License.