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cyclosaplin
General Information
DCTPep ID DCTPep00490
Peptide Name cyclosaplin
Sequence RLGDGCTR
Sequence Length 8
UniProt ID Not available
PubChem CID Not available
Origin somatic seedlings of sandalwood
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MDA-MB-231 | Breast adenocarcinoma | IC50=2.06 μg/mL | MTT assay | 24-72h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Normal fibroblast (L929) cell line: Peptide (0–1000 μg/mL) did not exhibit any cytotoxicity.
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C33H60N14O12S1
Absent amino acids AEFHIKMNPQSVWY
Theoretical pI 8.25
Acidic residues 1
Basic residues 2
Polar residues 4
Molecular weight (Average) 876.99
Molecular weight (Monoisotopic) 876.42
Common amino acids GR
Net charge 1
Instability index (II) 49.5
Aliphatic index 48.75
Grand average of hydropathicity (GRAVY) -0.963
Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24503375
Title Identification and structural characterization of a new pro-apoptotic cyclic octapeptide cyclosaplin from somatic seedlings of Santalum album L
Doi 10.1016/j.peptides.2014.01.023
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.