This work is licensed under a Creative Commons Attribution 4.0 International License.
Trichoplaxin
General Information
DCTPep ID DCTPep00491
Peptide Name Trichoplaxin
Sequence FFGRLKSVWSAVKHGWKAAKSR
Sequence Length 22
UniProt ID Not available
PubChem CID Not available
Origin Trichoplax adhaerens
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | IC50=45-50µM | MTT assay | 24h | 1 |
Hemolytic Activity Rat erythrocytes:20% Hemolysis=800µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00491
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C120H184N36O26
Absent amino acids CDEIMNPQTY
Theoretical pI 12.03
Acidic residues 0
Basic residues 7
Polar residues 5
Molecular weight (Average) 2547.01
Molecular weight (Monoisotopic) 2545.42
Common amino acids K
Net charge 7
Instability index (II) 14.03
Aliphatic index 57.73
Grand average of hydropathicity (GRAVY) -0.436
Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 11000
Abs 0.1% (=1 g/l) 4.319
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24530880
Title Trichoplaxin - a new membrane-active antimicrobial peptide from placozoan Cdna
Doi 10.1016/j.bbamem.2014.02.003
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.