Peptide Libraray

Chrysophsin-1

General Information

DCTPep ID DCTPep00497

Peptide Name Chrysophsin-1

Sequence FFGWLIKGAIHAGKAIHGLIHRRRH

Sequence Length 25

UniProt ID Not available

PubChem CID Not available

Origin Red sea bream

Type Native peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
DU145	Prostate carcinoma	~87%Inhibit=5 µg/mL	MTS assay	24 h	1
DU145	Prostate carcinoma	~87%Inhibit=5 µg/mL	MTS assay	24 h	1
DU145	Prostate carcinoma	~87%Inhibit=5 µg/mL	MTS assay	24 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity NIH3T3: ~35%Inhibit=5 µg/mL; WS-1: ~42%Inhibit=5 µg/mL

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00497

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C136H211N45O26

Absent amino acids CDEMNPQSTVY

Theoretical pI 12.31

Acidic residues 0

Basic residues 9

Polar residues 4

Molecular weight (Average) 2892.46

Molecular weight (Monoisotopic) 2890.66

Common amino acids GHI

Net charge 9

Instability index (II) 70.08

Aliphatic index 105.60

Grand average of hydropathicity (GRAVY) 0.000

Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 1.901

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 21349308

Title Characteristics of the antitumor activities in tumor cells and modulation of the inflammatory response in RAW264.7 cells of a novel antimicrobial peptide, chrysophsin-1, from the red sea bream (Chrysophrys major)

Doi 10.1016/j.peptides.2011.02.013

Year 2011

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available