This work is licensed under a Creative Commons Attribution 4.0 International License.
mt_E17L/L22 W/P27A
General Information
DCTPep ID DCTPep00502
Peptide Name mt_E17L/L22 W/P27A
Sequence LTFSDWWKLLAE
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin MDM2
Type Synthetic peptide
Classification
ACP Tumor active peptide Cancer targeted peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | IC50=15.1 µM | MTT assay | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target MDM2
Affinity Not available
Mechanism target the p53–MDM3 interaction
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C74H105N15O19
Absent amino acids CGHIMNPQRVY
Theoretical pI 4.37
Acidic residues 2
Basic residues 1
Polar residues 2
Molecular weight (Average) 1508.74
Molecular weight (Monoisotopic) 1507.77
Common amino acids L
Net charge -1
Instability index (II) 12.38
Aliphatic index 105.83
Grand average of hydropathicity (GRAVY) 0.150
Half Life
5.5 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 11000
Abs 0.1% (=1 g/l) 7.291
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24830845
Title Design of p53-derived peptides with cytotoxicity on breast cancer
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.