Latarcin-1

General Information


DCTPep ID  DCTPep00503

Peptide Name   Latarcin-1

Sequence  SMWSGMWRRKLKKLRNALKKKLKGE

Sequence Length  25

UniProt ID  Not available

PubChem CID  Not available

Origin  Lachesana tarabaevi

Type  Native peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
HepG2 Hepatoblastoma 50% Cell death=52.51±3.6 µM Non-Radioactive Cell Proliferation assay 72h 1

Hemolytic Activity  Rabbit erythrocytes: 20% Hemolysis=80 µM; Human erythrocytes: 36% Hemolysis=256 µg/ml

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep00503

(Please note that there is the predicted structure, predicted by AlphaFold)

SequenceNo structure available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C138H238N44O31S2

Absent amino acids  CDFHIPQTVY

Theoretical pI  11.77

Acidic residues  1

Basic residues  10

Polar residues  5

Molecular weight (Average)  3073.8

Molecular weight (Monoisotopic)  3071.78

Common amino acids  K

Net charge  9

Instability index (II)  18.36

Aliphatic index  66.40

Grand average of hydropathicity (GRAVY)  -1.248

Half Life 
  1.9 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 11000
  Abs 0.1% (=1 g/l) 3.579

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 24885331

Title  Identification of natural antimicrobial agents to treat dengue infection: In vitro analysis of latarcin peptide activity against dengue virus

Doi 10.1186/1471-2180-14-140

Year  2014

Literature 2

Pubmed ID 16735513

Title  Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity

Doi 10.1074/jbc.M602168200

Year  2006

Literature 3

Pubmed ID 34576320

Title  Membrane Interactions of Latarcins: Antimicrobial Peptides from Spider Venom

Doi 10.3390/ijms221810156

Year  2021

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.