Latarcin-1
General Information
DCTPep ID DCTPep00503
Peptide Name Latarcin-1
Sequence SMWSGMWRRKLKKLRNALKKKLKGE
Sequence Length 25
UniProt ID Not available
PubChem CID Not available
Origin Lachesana tarabaevi
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
Cell Line | Disease | Activity | Assay | Testing Time | Literature |
---|---|---|---|---|---|
HepG2 | Hepatoblastoma | 50% Cell death=52.51±3.6 µM | Non-Radioactive Cell Proliferation assay | 72h | 1 |
Hemolytic Activity Rabbit erythrocytes: 20% Hemolysis=80 µM; Human erythrocytes: 36% Hemolysis=256 µg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00503
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C138H238N44O31S2
Absent amino acids CDFHIPQTVY
Theoretical pI 11.77
Acidic residues 1
Basic residues 10
Polar residues 5
Molecular weight (Average) 3073.8
Molecular weight (Monoisotopic) 3071.78
Common amino acids K
Net charge 9
Instability index (II) 18.36
Aliphatic index 66.40
Grand average of hydropathicity (GRAVY) -1.248
Half Life
1.9 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 11000
Abs 0.1% (=1 g/l) 3.579
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24885331
Title Identification of natural antimicrobial agents to treat dengue infection: In vitro analysis of latarcin peptide activity against dengue virus
Year 2014
Literature 2
Pubmed ID 16735513
Title Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity
Year 2006
Literature 3
Pubmed ID 34576320
Title Membrane Interactions of Latarcins: Antimicrobial Peptides from Spider Venom
Year 2021
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available