This work is licensed under a Creative Commons Attribution 4.0 International License.
[D9k]Hymenochirin-1Pa
General Information
DCTPep ID DCTPep00513
Peptide Name [D9k]Hymenochirin-1Pa
Sequence LKLSPKTKkTLKKVLKGAIKGAIAIASMA
Sequence Length 29
UniProt ID Not available
PubChem CID Not available
Origin skin secretions of the frog Pseudhymenochirus merlini (Pipidae)
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | LC50=2.5±0.3 μM | CellTiter-Glo Luminescent Cell Viability assay | 24h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | LC50=5.4±0.4 μM | CellTiter-Glo Luminescent Cell Viability assay | 24h | 1 |
| HT-29 | Colon adenocarcinoma | LC50=6.3±1.9 μM | CellTiter-Glo Luminescent Cell Viability assay | 24h | 1 |
Hemolytic Activity Human red blood cells (RBC): LC50>400 μM
Normal (non-cancerous) Cytotoxicity HUVEC: LC50=9.3±0.3 μM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification k=D-Lys
Chiral Mix
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25241629
Title Conformational analysis and cytotoxic activities of the frog skin host-defense peptide, hymenochirin-1Pa
Doi 10.1016/j.peptides.2014.08.017
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.