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GN-8
General Information
DCTPep ID DCTPep00532
Peptide Name GN-8
Sequence IWKRWWWKR
Sequence Length 9
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | IC50=199µg/ml | MTT assay | 1h | 1 |
Hemolytic Activity Human erythrocytes:<=10% Hemolysis>400µg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C74H101N21O10
Absent amino acids ACDEFGHLMNPQSTVY
Theoretical pI 12.02
Acidic residues 0
Basic residues 4
Polar residues 0
Molecular weight (Average) 1444.75
Molecular weight (Monoisotopic) 1443.8
Common amino acids W
Net charge 4
Instability index (II) 144.98
Aliphatic index 43.33
Grand average of hydropathicity (GRAVY) -1.767
Half Life
20 hours (mammalian reticulocytes, in vitro).
30 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 22000
Abs 0.1% (=1 g/l) 15.228
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25941221
Title Antimicrobial activity of GN peptides and their mode of action
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.