GN-5

General Information


DCTPep ID  DCTPep00533

Peptide Name   GN-5

Sequence  KKRWWWWWR

Sequence Length  9

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
HeLa Human papillomavirus-related endocervical adenocarcinoma IC50=131µg/ml MTT assay 1h 1

Hemolytic Activity  Human erythrocytes:<=10% Hemolysis=100µg/ml

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C79H100N22O10

Absent amino acids  ACDEFGHILMNPQSTVY

Theoretical pI  12.02

Acidic residues  0

Basic residues  4

Polar residues  0

Molecular weight (Average)  1517.8

Molecular weight (Monoisotopic)  1516.8

Common amino acids  W

Net charge  4

Instability index (II)  108.76

Aliphatic index  0.00

Grand average of hydropathicity (GRAVY)  -2.367

Half Life 
  1.3 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  3 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 27500
  Abs 0.1% (=1 g/l) 18.118

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 25941221

Title  Antimicrobial activity of GN peptides and their mode of action

Doi 10.1128/AAC.00237-15

Year  2015

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.