DM5

General Information


DCTPep ID  DCTPep00542

Peptide Name   DM5

Sequence  GLFDIWKKLRWRR

Sequence Length  13

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
A549 Lung adenocarcinoma IC50=97.0±9.8µg/ml CellTiter 96® AQueous Non-Radioactive Cell Proliferation assay 24h 1

Hemolytic Activity  Human erythrocytes:10% Hemolysis>250µg/ml;50% Hemolysis>250µg/ml

Normal (non-cancerous) Cytotoxicity  NL20: 50% Cell death=179.2±3.8µg/ml

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep00542

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C85H132N26O16

Absent amino acids  ACEHMNPQSTVY

Theoretical pI  11.72

Acidic residues  1

Basic residues  5

Polar residues  1

Molecular weight (Average)  1774.15

Molecular weight (Monoisotopic)  1773.03

Common amino acids  R

Net charge  4

Instability index (II)  115.13

Aliphatic index  90.00

Grand average of hydropathicity (GRAVY)  -0.931

Half Life 
  30 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 11000
  Abs 0.1% (=1 g/l) 6.200

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 25985150

Title  In vitro properties of designed antimicrobial peptides that exhibit potent antipneumococcal activity and produces synergism in combination with penicillin

Doi 10.1038/srep09761

Year  2015

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.