Peptide Libraray

DM1

General Information

DCTPep ID DCTPep00545

Peptide Name DM1

Sequence GLFDKWAWWRWRR

Sequence Length 13

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	IC50=215.3±19.7µg/ml	CellTiter 96® AQueous Non-Radioactive Cell Proliferation assay	24h	1

Hemolytic Activity Human erythrocytes:10% Hemolysis>250µg/ml; 50% Hemolysis>250µg/ml

Normal (non-cancerous) Cytotoxicity NL20: 50% Cell death=221.8±7.8µg/ml

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00545

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C92H123N27O16

Absent amino acids CEHIMNPQSTVY

Theoretical pI 11.71

Acidic residues 1

Basic residues 4

Polar residues 1

Molecular weight (Average) 1863.16

Molecular weight (Monoisotopic) 1861.96

Common amino acids W

Net charge 3

Instability index (II) 88.75

Aliphatic index 37.69

Grand average of hydropathicity (GRAVY) -1.269

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 22000
Abs 0.1% (=1 g/l) 11.808

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 25985150

Title In vitro properties of designed antimicrobial peptides that exhibit potent antipneumococcal activity and produces synergism in combination with penicillin

Doi 10.1038/srep09761

Year 2015

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available