Compound 12

General Information


DCTPep ID  DCTPep00546

Peptide Name   Compound 12

Sequence  RTRCRfLRRC

Sequence Length  10

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
PC-12 Lung papillary adenocarcinoma IC50=225µg/ml WST-1 assay Not available 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Madin-Darby canine kidney cells: IC50=190µg/ml; Human dermal fibroblasts: IC50=164µg/ml

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys4<---Cys10

N-terminal Modification  C9

C-terminal Modification  Amidation

Other Modification  f=D-Phe

Chiral  Mix



Physicochemical Information


Formula  Not Applicable

Absent amino acids  Not Applicable

Theoretical pI  Not Applicable

Acidic residues  Not Applicable

Basic residues  Not Applicable

Polar residues  Not Applicable

Molecular weight (Average)  Not Applicable

Molecular weight (Monoisotopic)  Not Applicable

Common amino acids  Not Applicable

Net charge  Not Applicable

Instability index (II)  Not Applicable

Aliphatic index  Not Applicable

Grand average of hydropathicity (GRAVY)  Not Applicable

Half Life 
  Not Applicable

Extinction coefficients 
  Not Applicable

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 26024044

Title  A bioinspired peptide scaffold with high antibiotic activity and low in vivo toxicity

Doi 10.1038/srep10558

Year  2015

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.