Peptide Libraray

KL15

General Information

DCTPep ID DCTPep00553

Peptide Name KL15

Sequence KRKLYKWFAHLIKGL

Sequence Length 15

UniProt ID Not available

PubChem CID Not available

Origin membrane disrupting antimicrobial peptide KL15

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
CaCo-2	Colon adenocarcinoma	IC50=50 mg/ml	MTT assay	24h	1
SW480	Colon adenocarcinoma	IC50=50 mg/ml	MTT assay	24h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity H184B5F5/M10: IC50=150 μg/ml, testing time is 24h

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00553

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C94H149N25O17

Absent amino acids CDEMNPQSTV

Theoretical pI 10.58

Acidic residues 0

Basic residues 6

Polar residues 2

Molecular weight (Average) 1901.37

Molecular weight (Monoisotopic) 1900.16

Common amino acids K

Net charge 6

Instability index (II) 8.43

Aliphatic index 110.67

Grand average of hydropathicity (GRAVY) -0.360

Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 6990
Abs 0.1% (=1 g/l) 3.676

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 26147829

Title Anti-proliferative effect on a colon adenocarcinoma cell line exerted by a membrane disrupting antimicrobial peptide KL15

Doi 10.1080/15384047.2015.1056407

Year 2014

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available