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m5
General Information
DCTPep ID DCTPep00554
Peptide Name m5
Sequence LRLLDRWLRLFNRLLRWLRLLRGL
Sequence Length 24
UniProt ID Not available
PubChem CID Not available
Origin membrane disrupting antimicrobial peptide KL15
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| SW480 | Colon adenocarcinoma | IC50=100 mg/ml | MTT assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00554
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C149H250N48O28
Absent amino acids ACEHIKMPQSTVY
Theoretical pI 12.40
Acidic residues 1
Basic residues 7
Polar residues 2
Molecular weight (Average) 3161.93
Molecular weight (Monoisotopic) 3159.96
Common amino acids L
Net charge 6
Instability index (II) 101.05
Aliphatic index 178.75
Grand average of hydropathicity (GRAVY) 0.163
Half Life
5.5 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 11000
Abs 0.1% (=1 g/l) 3.479
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26147829
Title Anti-proliferative effect on a colon adenocarcinoma cell line exerted by a membrane disrupting antimicrobial peptide KL15
Doi 10.1080/15384047.2015.1056407
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.