Peptide Libraray

General Information

DCTPep ID DCTPep00555

Peptide Name m4

Sequence LRRLDRWLRLFNRLRRWFLRLLRGL

Sequence Length 25

UniProt ID Not available

PubChem CID Not available

Origin membrane disrupting antimicrobial peptide KL15

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
SW480	Colon adenocarcinoma	IC50=110 mg/ml	MTT assay	24h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00555

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C158H261N55O29

Absent amino acids ACEHIKMPQSTVY

Theoretical pI 12.54

Acidic residues 1

Basic residues 9

Polar residues 2

Molecular weight (Average) 3395.16

Molecular weight (Monoisotopic) 3393.06

Common amino acids LR

Net charge 8

Instability index (II) 138.29

Aliphatic index 140.40

Grand average of hydropathicity (GRAVY) -0.396

Half Life
5.5 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 11000
Abs 0.1% (=1 g/l) 3.240

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 26147829

Title Anti-proliferative effect on a colon adenocarcinoma cell line exerted by a membrane disrupting antimicrobial peptide KL15

Doi 10.1080/15384047.2015.1056407

Year 2014

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available