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m1
General Information
DCTPep ID DCTPep00557
Peptide Name m1
Sequence RLYRLYFRLYRLWRRLTL
Sequence Length 18
UniProt ID Not available
PubChem CID Not available
Origin membrane disrupting antimicrobial peptide KL15
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| SW480 | Colon adenocarcinoma | IC50=60 mg/ml | MTT assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00557
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C123H193N37O23
Absent amino acids ACDEGHIKMNPQSV
Theoretical pI 11.72
Acidic residues 0
Basic residues 6
Polar residues 4
Molecular weight (Average) 2558.12
Molecular weight (Monoisotopic) 2556.51
Common amino acids LR
Net charge 6
Instability index (II) 35.63
Aliphatic index 130.00
Grand average of hydropathicity (GRAVY) -0.383
Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 9970
Abs 0.1% (=1 g/l) 3.897
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26147829
Title Anti-proliferative effect on a colon adenocarcinoma cell line exerted by a membrane disrupting antimicrobial peptide KL15
Doi 10.1080/15384047.2015.1056407
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.