This work is licensed under a Creative Commons Attribution 4.0 International License.
LF11-322
General Information
DCTPep ID DCTPep00562
Peptide Name LF11-322
Sequence PFWRIRIRR
Sequence Length 9
UniProt ID Not available
PubChem CID Not available
Origin Human lactoferricin derived
Type Native peptide
Classification
Cancer therapy related peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| SBcl-2 | Serum B cell lymphoma 2 | LC50>100 µM | MTS assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Normal Human Dermal Fibroblasts (NHDF): LC50=65.1±0.3 µM
Target Not available
Affinity Not available
Mechanism Human lactoferricin derived di-peptides deploying loop structures induce apoptosis specifically in cancer cells through targeting membranous phosphatidylserin
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C61H98N22O10
Absent amino acids ACDEGHKLMNQSTVY
Theoretical pI 12.48
Acidic residues 0
Basic residues 4
Polar residues 0
Molecular weight (Average) 1299.59
Molecular weight (Monoisotopic) 1298.78
Common amino acids R
Net charge 4
Instability index (II) 93.93
Aliphatic index 86.67
Grand average of hydropathicity (GRAVY) -0.967
Half Life
>20 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
? (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 4.232
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26239537
Title Human lactoferricin derived di-peptides deploying loop structures induce apoptosis specifically in cancer cells through targeting membranous phosphatidylserine
Doi 10.1016/j.bbamem.2015.07.018
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.