Peptide Libraray

R-DIM-P-LF11-322

General Information

DCTPep ID DCTPep00563

Peptide Name R-DIM-P-LF11-322

Sequence PFWRIRIRRPRRIRIRWFP

Sequence Length 19

UniProt ID Not available

PubChem CID Not available

Origin Human lactoferricin derived

Type Native peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
SBcl-2	Serum B cell lymphoma 2	LC50=10.4±0.7 µM	MTS assay	24h	1
A-375	Amelanotic melanoma	LC50=23.3±1.7 µM	MTS assay	24h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Normal Human Dermal Fibroblasts (NHDF):LC50>101 µM

Target Not available

Affinity Not available

Mechanism Human lactoferricin derived di-peptides deploying loop structures induce apoptosis specifically in cancer cells through targeting membranous phosphatidylserin

Structure Information

PDB ID Not available

Predicted Structure DCTPep00563

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C127H201N45O20

Absent amino acids ACDEGHKLMNQSTVY

Theoretical pI 12.85

Acidic residues 0

Basic residues 8

Polar residues 0

Molecular weight (Average) 2678.28

Molecular weight (Monoisotopic) 2676.61

Common amino acids R

Net charge 8

Instability index (II) 126.36

Aliphatic index 82.11

Grand average of hydropathicity (GRAVY) -1.000

Half Life
>20 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
? (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 11000
Abs 0.1% (=1 g/l) 4.107

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 26239537

Title Human lactoferricin derived di-peptides deploying loop structures induce apoptosis specifically in cancer cells through targeting membranous phosphatidylserine

Doi 10.1016/j.bbamem.2015.07.018

Year 2015

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available