This work is licensed under a Creative Commons Attribution 4.0 International License.
RW-AH
General Information
DCTPep ID DCTPep00566
Peptide Name RW-AH
Sequence WWRRWWRRWRRWWRRWWR
Sequence Length 18
UniProt ID Not available
PubChem CID Not available
Origin Human lactoferricin derived
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| A-375 | Amelanotic melanoma | LC50=13.9±0.4 µM | MTS assay | 24h | 1 |
| SBcl-2 | Serum B cell lymphoma 2 | LC50=4.6±0.2 µM | MTS assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Normal Human Dermal Fibroblasts (NHDF): LC50=9.6±0.2 µM
Target Not available
Affinity Not available
Mechanism Human lactoferricin derived di-peptides deploying loop structures induce apoptosis specifically in cancer cells through targeting membranous phosphatidylserin
Structure Information
PDB ID Not available
Predicted Structure DCTPep00566
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C153H200N54O19
Absent amino acids ACDEFGHIKLMNPQSTVY
Theoretical pI 12.90
Acidic residues 0
Basic residues 9
Polar residues 0
Molecular weight (Average) 3099.62
Molecular weight (Monoisotopic) 3097.63
Common amino acids RW
Net charge 9
Instability index (II) 264.02
Aliphatic index 0.00
Grand average of hydropathicity (GRAVY) -2.700
Half Life
2.8 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 49500
Abs 0.1% (=1 g/l) 15.970
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26239537
Title Human lactoferricin derived di-peptides deploying loop structures induce apoptosis specifically in cancer cells through targeting membranous phosphatidylserine
Doi 10.1016/j.bbamem.2015.07.018
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.