Peptide Libraray

Chaxapeptin

General Information

DCTPep ID DCTPep00576

Peptide Name Chaxapeptin

Sequence GFGSKPLDSFGLNFF

Sequence Length 15

UniProt ID Not available

PubChem CID Not available

Origin Streptomyces leeuwenhoekii

Type Native peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	28% Inhibition=5µM(In a cell invasion assay); 56% Inhibition=50µM(In a cell invasion assay)	CyQuant stain assay (cell invasion)	36h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00576

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C79H109N17O21

Absent amino acids ACEHIMQRTVWY

Theoretical pI 5.84

Acidic residues 1

Basic residues 1

Polar residues 6

Molecular weight (Average) 1632.84

Molecular weight (Monoisotopic) 1631.8

Common amino acids F

Net charge 0

Instability index (II) 7.13

Aliphatic index 52.00

Grand average of hydropathicity (GRAVY) 0.233

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 26402731

Title Chaxapeptin, a Lasso Peptide from Extremotolerant Streptomyces leeuwenhoekii Strain C58 from the Hyperarid Atacama Desert

Doi 10.1021/acs.joc.5b01878

Year 2015

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available