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HPRP-A2
General Information
DCTPep ID DCTPep00579
Peptide Name HPRP-A2
Sequence fkklkklfsklwnwk
Sequence Length 15
UniProt ID Not available
PubChem CID Not available
Origin AMP
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| SGC-7901 | Human papillomavirus-related endocervical adenocarcinoma | IC50=10.42±0.30 μM | MTT assay | 24h | 1 |
| B16 | Mouse melanoma | IC50=19.16±0.38 μM | MTT assay | 24h | 1 |
| PC-3 | Prostate carcinoma | IC50=21.38±0.56 μM | MTT assay | 24h | 1 |
| BGC-823 | Human papillomavirus-related endocervical adenocarcinoma | IC50=8.65 ±0.38 μM | MTT assay | 24h | 1 |
Hemolytic Activity Human red blood cells: low toxicity
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral D
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) 1994.5
Molecular weight (Monoisotopic) 1993.2
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26422386
Title In vitro Characterization of the Rapid Cytotoxicity of Anticancer Peptide HPRP-A2 through Membrane Destruction and Intracellular Mechanism against Gastric Cancer Cell Lines
Doi 10.1371/journal.pone.0139578
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.