DCTPep ID  DCTPep00580

Peptide Name   Ctn[15-34]

Sequence  KKRLKKIFKKPMVIGVTIPF

Sequence Length  20

UniProt ID  U5KJJ0 

PubChem CID  Not available

Origin  Rattlesnake Venom Cathelicidin

Type  Native peptide

Hemolytic Activity  Human erythrocytes: nonhemolytic up to 400 μM, and their equimolar mixture at that concentration caused only 7% hemolysis

Normal (non-cancerous) Cytotoxicity  Human Splenic Fibroblasts (HSF): IC50=12.78±0.33 µg/mL; Endometrial epithelial cells(HEEC): IC50=2.66±0.34 µg/mL; HPDE6c7 Human Pancreatic Duct Epithelial Cell: IC50=3.45±0.20 µg/mL; Normal Human Hepatic Cell (Lo-2): IC50=2.91±0.07 µg/mL; NCM460: IC50=3.04±0.10 µg/mL; CCD-19Lu: IC50=4.76±0.03 µg/mL

Target  Not available

Affinity  Not available

Mechanism  Not available

PDB ID  2MWT 

Predicted Structure  DCTPep00580

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L

Grand average of hydropathicity (GRAVY)  0.050

Half Life 
  1.3 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  3 min (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature 1

Pubmed ID 26465972

Title  Structural Dissection of Crotalicidin, a Rattlesnake Venom Cathelicidin, Retrieves a Fragment with Antimicrobial and Antitumor Activity

Doi 10.1021/acs.jmedchem.5b01142

Year  2015

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available