This work is licensed under a Creative Commons Attribution 4.0 International License.
Pseudhymenochirin-1Pb [E17k]
General Information
DCTPep ID DCTPep00586
Peptide Name Pseudhymenochirin-1Pb [E17k]
Sequence IKIPSFFRNILKKVGKkAVSLIAGALKQS
Sequence Length 29
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HT-29 | Colon adenocarcinoma | IC50=11±2µM | CellTiter-Glo Luminescent Cell Viability Assay | 24h | 1 |
| A549 | Lung adenocarcinoma | IC50=2.1±0.7µM | CellTiter-Glo Luminescent Cell Viability Assay | 24h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | IC50=3.6±0.5µM | CellTiter-Glo Luminescent Cell Viability Assay | 24h | 1 |
Hemolytic Activity Mouse erythrocytes:50% Hemolysis=19±4µM
Normal (non-cancerous) Cytotoxicity HUVEC: 50% Cell death=5.0±0.5µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification k=D-Lys
Chiral Mix
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26606380
Title Conformational Analysis of the Host-Defense Peptides Pseudhymenochirin-1Pb and -2Pa and Design of Analogues with Insulin-Releasing Activities and Reduced Toxicities
Doi 10.1021/acs.jnatprod.5b00843
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.