This work is licensed under a Creative Commons Attribution 4.0 International License.
B4
General Information
DCTPep ID DCTPep00589
Peptide Name B4
Sequence IRKLKSWKWLRWL
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Not active up to 170 µM | Trypan Blue exclusion assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00589
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C90H141N25O15
Absent amino acids ACDEFGHMNPQTVY
Theoretical pI 12.02
Acidic residues 0
Basic residues 5
Polar residues 1
Molecular weight (Average) 1813.27
Molecular weight (Monoisotopic) 1812.1
Common amino acids KLW
Net charge 5
Instability index (II) 74.03
Aliphatic index 120.00
Grand average of hydropathicity (GRAVY) -0.638
Half Life
20 hours (mammalian reticulocytes, in vitro).
30 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 16500
Abs 0.1% (=1 g/l) 9.100
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26902758
Title Combined Bioinformatic and Rational Design Approach To Develop Antimicrobial Peptides against Mycobacterium tuberculosis
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.