Peptide Libraray

KL1

General Information

DCTPep ID DCTPep00590

Peptide Name KL1

Sequence KLLKLLKKLLKLLK

Sequence Length 14

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	IC50=3.3±0.4 μM	MTT assay	24h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00590

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C84H162N20O15

Absent amino acids ACDEFGHIMNPQRSTVWY

Theoretical pI 10.70

Acidic residues 0

Basic residues 6

Polar residues 0

Molecular weight (Average) 1692.34

Molecular weight (Monoisotopic) 1691.25

Common amino acids L

Net charge 6

Instability index (II) -39.23

Aliphatic index 222.86

Grand average of hydropathicity (GRAVY) 0.500

Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 27195657

Title Amphipathicity Determines Different Cytotoxic Mechanisms of Lysine- or Arginine-Rich Cationic Hydrophobic Peptides in Cancer Cells

Doi 10.1021/acs.jmedchem.5b02016

Year 2016

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available