Peptide Libraray

Api796

General Information

DCTPep ID DCTPep00596

Peptide Name Api796

Sequence XIXIXIXRPVYXPRPRPPHPRL

Sequence Length 22

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Cancer therapy related peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	IC50>600µg/ml	MTT assay	24h	1

Hemolytic Activity Human erythrocytes:0% Hemolysis=100-600µg/ml

Normal (non-cancerous) Cytotoxicity HEK293: 50% Cell death>600µg/ml

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification gu=N , N , N ', N'-tetramethylguanidino)

C-terminal Modification Free

Other Modification X=Orn

Chiral L

Physicochemical Information

Formula Not Applicable

Absent amino acids Not Applicable

Theoretical pI Not Applicable

Acidic residues Not Applicable

Basic residues Not Applicable

Polar residues Not Applicable

Molecular weight (Average) Not Applicable

Molecular weight (Monoisotopic) Not Applicable

Common amino acids Not Applicable

Net charge Not Applicable

Instability index (II) Not Applicable

Aliphatic index Not Applicable

Grand average of hydropathicity (GRAVY) Not Applicable

Half Life
Not Applicable

Extinction coefficients
Not Applicable

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 27243004

Title N-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa

Doi 2016

Year

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available