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V681 [V13A]
General Information
DCTPep ID DCTPep00600
Peptide Name V681 [V13A]
Sequence KWKSFLKTFKSAAKTVLHTALKAISS
Sequence Length 26
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| SGC-7901 | Human papillomavirus-related endocervical adenocarcinoma | IC50=2.33 µM | MTT assay | 24h | 1 |
| B16 | Mouse melanoma | IC50=3.62 µM | MTT assay | 24h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | IC50=5.52 µM | MTT assay | 24h | 1 |
| A549 | Lung adenocarcinoma | IC50=6.83 µM | MTT assay | 24h | 1 |
Hemolytic Activity Human erythrocytes: <5% Hemolysis=16 µM
Normal (non-cancerous) Cytotoxicity 3T3-L1: 50% Cell death=6.79 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00600
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C136H223N35O34
Absent amino acids CDEGMNPQRY
Theoretical pI 10.70
Acidic residues 0
Basic residues 7
Polar residues 7
Molecular weight (Average) 2892.48
Molecular weight (Monoisotopic) 2890.68
Common amino acids K
Net charge 7
Instability index (II) 6.56
Aliphatic index 86.54
Grand average of hydropathicity (GRAVY) 0.004
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 1.901
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27363513
Title Specificity and mechanism of action of alpha-helical membrane-active peptides interacting with model and biological membranes by single-molecule force spectroscopy
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.