Peptide Libraray

Warnericin RK [G20D]

General Information

DCTPep ID DCTPep00613

Peptide Name Warnericin RK [G20D]

Sequence MQFITDLIKKAVDFFKGLFDNK

Sequence Length 22

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide Membrane lysis

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
Jurkat	Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia	LD50=5.39µM	PI staining assay	Not available	1

Hemolytic Activity Human erythrocytes:10% Hemolysis=12.36µM

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00613

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C124H192N28O32S1

Absent amino acids CEHPRSWY

Theoretical pI 8.19

Acidic residues 3

Basic residues 4

Polar residues 3

Molecular weight (Average) 2619.12

Molecular weight (Monoisotopic) 2617.4

Common amino acids FK

Net charge 1

Instability index (II) -5.75

Aliphatic index 88.64

Grand average of hydropathicity (GRAVY) 0.068

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 27598770

Title Specific Anti-Leukemic Activity of the Peptide Warnericin RK and Analogues and Visualization of Their Effect on Cancer Cells by Chemical Raman Imaging

Doi 10.1371/journal.pone.0162007

Year 2016

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available