Warnericin RK [F14V]

General Information


DCTPep ID  DCTPep00614

Peptide Name   Warnericin RK [F14V]

Sequence  MQFITDLIKKAVDVFKGLFGNK

Sequence Length  22

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide Membrane lysis



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
Jurkat Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia LD50=8.79µM PI staining assay Not available 1

Hemolytic Activity  Human erythrocytes:10% Hemolysis=12.5µM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep00614

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C118H190N28O30S1

Absent amino acids  CEHPRSWY

Theoretical pI  9.52

Acidic residues  2

Basic residues  4

Polar residues  4

Molecular weight (Average)  2513.04

Molecular weight (Monoisotopic)  2511.39

Common amino acids  K

Net charge  2

Instability index (II)  -11.79

Aliphatic index  101.82

Grand average of hydropathicity (GRAVY)  0.273

Half Life 
  30 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 27598770

Title  Specific Anti-Leukemic Activity of the Peptide Warnericin RK and Analogues and Visualization of Their Effect on Cancer Cells by Chemical Raman Imaging

Doi 10.1371/journal.pone.0162007

Year  2016

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.