Saha-CATH1
General Information
DCTPep ID DCTPep00616
Peptide Name Saha-CATH1
Sequence GIKHILFMAKTKLPRATCTAEIKENCDRKK
Sequence Length 30
UniProt ID Not available
PubChem CID Not available
Origin Sarcophilus harrisii
Type Native peptide
Classification
Cancer therapy related peptides
Activity Information
Cell Line | Disease | Activity | Assay | Testing Time | Literature |
---|---|---|---|---|---|
A549 | Lung adenocarcinoma | Not active up to 500µg/ml | Alamar blue assay | 24h | 1 |
Hemolytic Activity Human erythrocytes:5% Hemolysis=1-500µg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00616
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C150H259N45O41S3
Absent amino acids QSVWY
Theoretical pI 9.79
Acidic residues 3
Basic residues 9
Polar residues 7
Molecular weight (Average) 3445.16
Molecular weight (Monoisotopic) 3442.87
Common amino acids K
Net charge 6
Instability index (II) 47.67
Aliphatic index 75.00
Grand average of hydropathicity (GRAVY) -0.583
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 125
Abs 0.1% (=1 g/l) 0.036, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27725697
Title Cathelicidins in the Tasmanian devil (Sarcophilus harrisii)
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available