Peptide Libraray

Saha-CATH1

General Information

DCTPep ID DCTPep00616

Peptide Name Saha-CATH1

Sequence GIKHILFMAKTKLPRATCTAEIKENCDRKK

Sequence Length 30

UniProt ID Not available

PubChem CID Not available

Origin Sarcophilus harrisii

Type Native peptide

Classification

Cancer therapy related peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	Not active up to 500µg/ml	Alamar blue assay	24h	1

Hemolytic Activity Human erythrocytes:5% Hemolysis=1-500µg/ml

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00616

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C150H259N45O41S3

Absent amino acids QSVWY

Theoretical pI 9.79

Acidic residues 3

Basic residues 9

Polar residues 7

Molecular weight (Average) 3445.16

Molecular weight (Monoisotopic) 3442.87

Common amino acids K

Net charge 6

Instability index (II) 47.67

Aliphatic index 75.00

Grand average of hydropathicity (GRAVY) -0.583

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 125
Abs 0.1% (=1 g/l) 0.036, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 27725697

Title Cathelicidins in the Tasmanian devil (Sarcophilus harrisii)

Doi 10.1038/srep35019

Year 2016

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available