Peptide Libraray

Saha-CATH6

General Information

DCTPep ID DCTPep00619

Peptide Name Saha-CATH6

Sequence KRIRFFERIRDRLRDLGNRIKNRIRDFFS

Sequence Length 29

UniProt ID Not available

PubChem CID Not available

Origin Sarcophilus harrisii

Type Native peptide

Classification

Cancer therapy related peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	Not active up to 250 µg/ml	Alamar blue assay	24h	1

Hemolytic Activity Human erythrocytes:8% Hemolysis=31.25µg/ml; Human erythrocytes:10% Hemolysis=62.5µg/ml; Human erythrocytes:12% Hemolysis=125µg/ml

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00619

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C168H278N60O41

Absent amino acids ACHMPQTVWY

Theoretical pI 11.91

Acidic residues 4

Basic residues 11

Polar residues 4

Molecular weight (Average) 3794.43

Molecular weight (Monoisotopic) 3792.15

Common amino acids R

Net charge 7

Instability index (II) 16.48

Aliphatic index 80.69

Grand average of hydropathicity (GRAVY) -1.162

Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 27725697

Title Cathelicidins in the Tasmanian devil (Sarcophilus harrisii)

Doi 10.1038/srep35019

Year 2016

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available