Saha-CATH6

General Information


DCTPep ID  DCTPep00619

Peptide Name   Saha-CATH6

Sequence  KRIRFFERIRDRLRDLGNRIKNRIRDFFS

Sequence Length  29

UniProt ID  Not available

PubChem CID  Not available

Origin  Sarcophilus harrisii

Type  Native peptide

Classification

  

Cancer therapy related peptides



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
A549 Lung adenocarcinoma Not active up to 250 µg/ml Alamar blue assay 24h 1

Hemolytic Activity  Human erythrocytes:8% Hemolysis=31.25µg/ml; Human erythrocytes:10% Hemolysis=62.5µg/ml; Human erythrocytes:12% Hemolysis=125µg/ml

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep00619

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C168H278N60O41

Absent amino acids  ACHMPQTVWY

Theoretical pI  11.91

Acidic residues  4

Basic residues  11

Polar residues  4

Molecular weight (Average)  3794.43

Molecular weight (Monoisotopic)  3792.15

Common amino acids  R

Net charge  7

Instability index (II)  16.48

Aliphatic index  80.69

Grand average of hydropathicity (GRAVY)  -1.162

Half Life 
  1.3 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  3 min (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 27725697

Title  Cathelicidins in the Tasmanian devil (Sarcophilus harrisii)

Doi 10.1038/srep35019

Year  2016

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.