This work is licensed under a Creative Commons Attribution 4.0 International License.
SFTI-polyR-L1
General Information
DCTPep ID DCTPep00630
Peptide Name SFTI-polyR-L1
Sequence CRRKRRRICFPDGR
Sequence Length 14
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Cancer targeted peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | IC50=28.72±0.15 μM | MTT assay | 48h | 1 |
| HT-29 | Colon adenocarcinoma | IC50=82.27±0.13 μM | MTT assay | 48h | 1 |
| PC-3 | Prostate carcinoma | IC50>100 μM | MTT assay | 48h | 1 |
Hemolytic Activity Human red blood cells: no hemolytic activity(as show in Fig.4)
Normal (non-cancerous) Cytotoxicity HUVEC: IC50>100 μM
Target pigment epithelium-derived factor; somatostatin
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00630
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C74H131N33O17S2
Absent amino acids AEHLMNQSTVWY
Theoretical pI 11.71
Acidic residues 1
Basic residues 7
Polar residues 3
Molecular weight (Average) 1819.19
Molecular weight (Monoisotopic) 1817.98
Common amino acids R
Net charge 6
Instability index (II) 163.69
Aliphatic index 27.86
Grand average of hydropathicity (GRAVY) -1.721
Half Life
1.2 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 125
Abs 0.1% (=1 g/l) 0.069, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27734947
Title Dual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.