SFTI-SST-01

General Information


DCTPep ID  DCTPep00635

Peptide Name   SFTI-SST-01

Sequence  CTKSIPPICYwKV

Sequence Length  13

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide Cancer targeted peptides



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
HT-29 Colon adenocarcinoma IC50=45.38±0.03 μM MTT assay 48h 1
MCF-7 Invasive breast carcinoma of no special type IC50=46.07±0.05 μM MTT assay 48h 1
PC-3 Prostate carcinoma IC50>100 μM MTT assay 48h 1

Hemolytic Activity  Human red blood cells: no hemolytic activity(as show in Fig.4)

Normal (non-cancerous) Cytotoxicity  HUVEC: IC50=18.32±0.05 μM

Target  pigment epithelium-derived factor; somatostatin

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  w=D-Tryptophane

Chiral  Mix



Physicochemical Information


Formula  Not Applicable

Absent amino acids  Not Applicable

Theoretical pI  Not Applicable

Acidic residues  Not Applicable

Basic residues  Not Applicable

Polar residues  Not Applicable

Molecular weight (Average)  Not Applicable

Molecular weight (Monoisotopic)  Not Applicable

Common amino acids  Not Applicable

Net charge  Not Applicable

Instability index (II)  Not Applicable

Aliphatic index  Not Applicable

Grand average of hydropathicity (GRAVY)  Not Applicable

Half Life 
  Not Applicable

Extinction coefficients 
  Not Applicable

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 27734947

Title  Dual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy

Doi 10.1038/srep35347

Year  2016

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.