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polyR
General Information
DCTPep ID DCTPep00637
Peptide Name polyR
Sequence RRKRRR
Sequence Length 6
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Cancer targeted peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | IC50=83.51±0.46 μM | MTT assay | 48h | 1 |
| HT-29 | Colon adenocarcinoma | IC50>100 μM | MTT assay | 48h | 1 |
| PC-3 | Prostate carcinoma | IC50>100 μM | MTT assay | 48h | 1 |
Hemolytic Activity Human red blood cells: no hemolytic activity(as show in Fig.4)
Normal (non-cancerous) Cytotoxicity HUVEC: IC50=44.64±0.03 μM
Target pigment epithelium-derived factor; somatostatin
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C36H74N22O7
Absent amino acids ACDEFGHILMNPQSTVWY
Theoretical pI 12.60
Acidic residues 0
Basic residues 6
Polar residues 0
Molecular weight (Average) 927.13
Molecular weight (Monoisotopic) 926.61
Common amino acids R
Net charge 6
Instability index (II) 349.07
Aliphatic index 0.00
Grand average of hydropathicity (GRAVY) -4.400
Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27734947
Title Dual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.