Peptide Libraray

PEDF

General Information

DCTPep ID DCTPep00638

Peptide Name PEDF

Sequence YHLNQPF

Sequence Length 7

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Cancer targeted peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HT-29	Colon adenocarcinoma	IC50>100 μM	MTT assay	48h	1
MCF-7	Invasive breast carcinoma of no special type	IC50>100 μM	MTT assay	48h	1
PC-3	Prostate carcinoma	IC50>100 μM	MTT assay	48h	1

Hemolytic Activity Human red blood cells: no hemolytic activity(as show in Fig.4)

Normal (non-cancerous) Cytotoxicity HUVEC: IC50=19.40±0.08 μM

Target pigment epithelium-derived factor; somatostatin

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C44H59N11O11

Absent amino acids ACDEGIKMRSTVW

Theoretical pI 6.74

Acidic residues 0

Basic residues 1

Polar residues 2

Molecular weight (Average) 918.02

Molecular weight (Monoisotopic) 917.44

Common amino acids FHLNPQY

Net charge 1

Instability index (II) 70.46

Aliphatic index 55.71

Grand average of hydropathicity (GRAVY) -0.929

Half Life
2.8 hours (mammalian reticulocytes, in vitro).
10 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 1.623

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 27734947

Title Dual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy

Doi 10.1038/srep35347

Year 2016

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available