Peptide Libraray

IL-2

General Information

DCTPep ID DCTPep00641

Peptide Name IL-2

Sequence FKIGGFAKKLWRSLLA

Sequence Length 16

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
PC-3	Prostate carcinoma	IC50=43.6±7.9 μM	MTT assay	2h	1
HeLa	Human papillomavirus-related endocervical adenocarcinoma	IC50=52.0±5.8 μM	MTT assay	2h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity HEK293T: IC50=40.0±5.5 μM; WPMY-1: IC50=19.4±5.3 μM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00641

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C90H143N23O18

Absent amino acids CDEHMNPQTVY

Theoretical pI 11.26

Acidic residues 0

Basic residues 4

Polar residues 3

Molecular weight (Average) 1835.27

Molecular weight (Monoisotopic) 1834.1

Common amino acids KL

Net charge 4

Instability index (II) 39.34

Aliphatic index 110.00

Grand average of hydropathicity (GRAVY) 0.400

Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.997

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 27778166

Title Isoleucine/leucine residues at "a" and "d" positions of a heptad repeat sequence are crucial for the cytolytic activity of a short anticancer lytic peptide

Doi 10.1007/s00726-016-2350-9

Year 2017

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available