BmKn-22

General Information


DCTPep ID  DCTPep00646

Peptide Name   BmKn-22

Sequence  FIGAIARLLSK

Sequence Length  11

UniProt ID  Not available

PubChem CID  Not available

Origin  Scorpion venom

Type  Native peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
HSC-4 Tongue squamous cell carcinoma; Squamous cell carcinoma of the oral tongue IC50=97 μg/mL MTT assay 24h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  BmKn-2 exerts selective cytotoxic effects on human oral cancer cells by inducting apoptosis via a p53-dependent intrinsic apoptotic pathway. BmKn-2 peptide originally derived from a natural source shows great promise as a candidate treatment for oral cancer



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C56H97N15O13

Absent amino acids  CDEHMNPQTVWY

Theoretical pI  11.00

Acidic residues  0

Basic residues  2

Polar residues  2

Molecular weight (Average)  1188.48

Molecular weight (Monoisotopic)  1187.74

Common amino acids  AIL

Net charge  2

Instability index (II)  1.37

Aliphatic index  160.00

Grand average of hydropathicity (GRAVY)  1.218

Half Life 
  1.1 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 27780132

Title  The scorpion venom peptide BmKn2 induces apoptosis in cancerous but not in normal human oral cells

Doi 10.1016/j.biopha.2016.10.041

Year  2015

Literature 2

Pubmed ID 25854366

Title  BmKn-2 scorpion venom peptide for killing oral cancer cells by apoptosis

Doi 10.7314/apjcp.2015.16.7.2807

Year  2015

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.