This work is licensed under a Creative Commons Attribution 4.0 International License.
BmKn-2
General Information
DCTPep ID DCTPep00647
Peptide Name BmKn-2
Sequence FIGAIARLLSKIF
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin Scorpion venom
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HSC-4 | Tongue squamous cell carcinoma; Squamous cell carcinoma of the oral tongue | IC50=26 μg/mL | MTT assay | 24h | 1 |
| HSC-4 | Tongue squamous cell carcinoma; Squamous cell carcinoma of the oral tongue | IC50=29 μg/mL | MTT assay | 24h | 1 |
| KB | Human papillomavirus-related endocervical adenocarcinoma | IC50=34 μg/mL | MTT assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism BmKn-2 exerts selective cytotoxic effects on human oral cancer cells by inducting apoptosis via a p53-dependent intrinsic apoptotic pathway. BmKn-2 peptide originally derived from a natural source shows great promise as a candidate treatment for oral cancer
Structure Information
PDB ID Not available
Predicted Structure DCTPep00647
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C71H117N17O15
Absent amino acids CDEHMNPQTVWY
Theoretical pI 11.00
Acidic residues 0
Basic residues 2
Polar residues 2
Molecular weight (Average) 1448.81
Molecular weight (Monoisotopic) 1447.89
Common amino acids I
Net charge 2
Instability index (II) -3.83
Aliphatic index 165.38
Grand average of hydropathicity (GRAVY) 1.592
Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27780132
Title The scorpion venom peptide BmKn2 induces apoptosis in cancerous but not in normal human oral cells
Doi 10.1016/j.biopha.2016.10.041
Year 2015
Literature 2
Pubmed ID 25854366
Title BmKn-2 scorpion venom peptide for killing oral cancer cells by apoptosis
Doi 10.7314/apjcp.2015.16.7.2807
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.