Peptide Libraray

TetraF2W-RK

General Information

DCTPep ID DCTPep00651

Peptide Name TetraF2W-RK

Sequence WWWLRKIW

Sequence Length 8

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Cancer therapy related peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	LC50>100µM	MTS assay	Not available	1

Hemolytic Activity Human erythrocytes:50% Hemolysis=30µM; Pig erythrocytes:50% Hemolysis=40µM; Chicken erythrocytes:50% Hemolysis=35µM

Normal (non-cancerous) Cytotoxicity HEK293:50% Cell death=60µM; HaCat:50% Cell death=60µM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C68H88N16O9

Absent amino acids ACDEFGHMNPQSTVY

Theoretical pI 11.00

Acidic residues 0

Basic residues 2

Polar residues 0

Molecular weight (Average) 1273.55

Molecular weight (Monoisotopic) 1272.69

Common amino acids W

Net charge 2

Instability index (II) 37.64

Aliphatic index 97.50

Grand average of hydropathicity (GRAVY) -0.463

Half Life
2.8 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 22000
Abs 0.1% (=1 g/l) 17.275

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 27915018

Title Design and surface immobilization of short anti-biofilm peptides

Doi 10.1016/j.actbio.2016.11.061

Year 2017

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available