TetraF2W-RK

General Information


DCTPep ID  DCTPep00651

Peptide Name   TetraF2W-RK

Sequence  WWWLRKIW

Sequence Length  8

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer therapy related peptides



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
HeLa Human papillomavirus-related endocervical adenocarcinoma LC50>100µM MTS assay Not available 1

Hemolytic Activity  Human erythrocytes:50% Hemolysis=30µM; Pig erythrocytes:50% Hemolysis=40µM; Chicken erythrocytes:50% Hemolysis=35µM

Normal (non-cancerous) Cytotoxicity  HEK293:50% Cell death=60µM; HaCat:50% Cell death=60µM

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C68H88N16O9

Absent amino acids  ACDEFGHMNPQSTVY

Theoretical pI  11.00

Acidic residues  0

Basic residues  2

Polar residues  0

Molecular weight (Average)  1273.55

Molecular weight (Monoisotopic)  1272.69

Common amino acids  W

Net charge  2

Instability index (II)  37.64

Aliphatic index  97.50

Grand average of hydropathicity (GRAVY)  -0.463

Half Life 
  2.8 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 22000
  Abs 0.1% (=1 g/l) 17.275

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 27915018

Title  Design and surface immobilization of short anti-biofilm peptides

Doi 10.1016/j.actbio.2016.11.061

Year  2017

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.