This work is licensed under a Creative Commons Attribution 4.0 International License.
Leucocin A (18-35)
General Information
DCTPep ID DCTPep00653
Peptide Name Leucocin A (18-35)
Sequence WGEAFSAGVHRLANGGNG
Sequence Length 18
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HepG2 | Hepatoblastoma | IC50>64µM | MTT assay | 24h | 1 |
Hemolytic Activity Human erythrocytes:10% Hemolysis>71.15µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00653
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C78H114N26O24
Absent amino acids CDIKMPQTY
Theoretical pI 6.75
Acidic residues 1
Basic residues 2
Polar residues 8
Molecular weight (Average) 1799.92
Molecular weight (Monoisotopic) 1798.85
Common amino acids G
Net charge 1
Instability index (II) -15.07
Aliphatic index 54.44
Grand average of hydropathicity (GRAVY) -0.317
Half Life
2.8 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 3.056
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28002968
Title Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles
Doi 10.1021/acs.jmedchem.6b00922
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.