Leucocin A (18-35)[G2,8,15,16L;E3R;S6R;A7R;H10R;N14,17R;G18R]

General Information


DCTPep ID  DCTPep00660

Peptide Name   Leucocin A (18-35)[G2,8,15,16L;E3R;S6R;A7R;H10R;N14,17R;G18R]

Sequence  WLRAFRRLVRRLARLLRR

Sequence Length  18

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer therapy related peptides



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
HepG2 Hepatoblastoma IC50>64µM MTT assay 24h 1

Hemolytic Activity  Human erythrocytes:10% Hemolysis=53.18µM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep00660

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C109H191N43O19

Absent amino acids  CDEGHIKMNPQSTY

Theoretical pI  12.85

Acidic residues  0

Basic residues  8

Polar residues  0

Molecular weight (Average)  2407.99

Molecular weight (Monoisotopic)  2406.53

Common amino acids  R

Net charge  8

Instability index (II)  133.17

Aliphatic index  135.56

Grand average of hydropathicity (GRAVY)  -0.406

Half Life 
  2.8 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 5500
  Abs 0.1% (=1 g/l) 2.284

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 28002968

Title  Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles

Doi 10.1021/acs.jmedchem.6b00922

Year  2016

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.