Peptide Libraray

Leucocin A (18-35)[G2,8,15,16L;E3R;S6R;A7R;H10R;N14,17R;G18R]

General Information

DCTPep ID DCTPep00660

Peptide Name Leucocin A (18-35)[G2,8,15,16L;E3R;S6R;A7R;H10R;N14,17R;G18R]

Sequence WLRAFRRLVRRLARLLRR

Sequence Length 18

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Cancer therapy related peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HepG2	Hepatoblastoma	IC50>64µM	MTT assay	24h	1

Hemolytic Activity Human erythrocytes:10% Hemolysis=53.18µM

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00660

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C109H191N43O19

Absent amino acids CDEGHIKMNPQSTY

Theoretical pI 12.85

Acidic residues 0

Basic residues 8

Polar residues 0

Molecular weight (Average) 2407.99

Molecular weight (Monoisotopic) 2406.53

Common amino acids R

Net charge 8

Instability index (II) 133.17

Aliphatic index 135.56

Grand average of hydropathicity (GRAVY) -0.406

Half Life
2.8 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.284

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 28002968

Title Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles

Doi 10.1021/acs.jmedchem.6b00922

Year 2016

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available