Peptide Libraray

Peptide 35409

General Information

DCTPep ID DCTPep00661

Peptide Name Peptide 35409

Sequence RYRRKKKMKKALQYIKLLKE

Sequence Length 20

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Cancer therapy related peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	Not active up to 44 µg/ml	Resazurine assay	72h	1
HepG2	Hepatoblastoma	Not active up to 44 µg/ml	Resazurine assay	72h	1

Hemolytic Activity Human erythrocytes: 14% Hemolysis=350µM

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00661

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C120H213N37O26S1

Absent amino acids CDFGHNPSTVW

Theoretical pI 10.82

Acidic residues 1

Basic residues 10

Polar residues 2

Molecular weight (Average) 2622.3

Molecular weight (Monoisotopic) 2620.62

Common amino acids K

Net charge 9

Instability index (II) 42.01

Aliphatic index 83.00

Grand average of hydropathicity (GRAVY) -1.540

Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 2980
Abs 0.1% (=1 g/l) 1.136

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 28066341

Title A New Synthetic Peptide Having Two Target of Antibacterial Action in E. coli ML35

Doi 10.3389/fmicb.2016.02006

Year 2016

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available